Police are appealing for information following Thursday’s (Oct 10) collision on Bitterne Road West.
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It happened at around 6.36pm and involved a white BMW and a purple Toyota.
Three people suffered minor injuries and were taken to hospital for treatment.
Anyone with information can contact Hampshire Constabulary on 101 quoting 44240441439, or via their website.
The incident reportedly brought Bitterne Road West - the official eastbound diversion route during the St Denys Road bridge repairs - to a standstill and resulted in a partial road closure in both directions for a period.