Jewellery including gold and diamond earrings worth £600 and a watch worth £200 were taken along with around £1000 in cash from a Bullar Road address in Bitterne Park on Friday, September 11.
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It happened between 7.30 and 9pm.
Police are asking anyone who saw anything suspicious around the time of the burglary, or has any information, to contact PC Matt Blake in the Operation Hawk team at Southampton central Police Station on 101, quoting 44160426789.
Alternatively you can call Crimestoppers anonymously on 0800 555 111.